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Trimipramine – Usages, Side effects, Risk factors, Precautions
Here in this post, we are discussing “trimipramine “. You can read usages, side effects, Risk factors, and warning information. Keep visiting Psychology Roots.
About Trimipramine
Trimipramine is an antidepressant TCAs.
Brand name
Trimipramine is available with the following brand name.
- Surmontil
- Trimip
- Tripramine
Forms of Trimipramine
Trimipramine is available in the following form
- Capsule
Capsule
Trimipramine capsules are available in the following doses
- 25mg
- 50mg
- 100mg
Trimipramine – Usages, Side effects, Risk factors, Precautions
Disorder to treat
It is used for the treatment of the following disorder
Depression
Adults
- Initially, 50-75mg orally per day is given in divided doses. doses should be gradually increased every 2-3 weeks
- Maintenance dose: 50-100 mg orally per day.
- If may increase up to 200mg per day if needed.
Children
- <12 years: Safety and efficacy not established.
- ≥12 years: Initially 50 mg per day is given. It may increase up to 100 mg per day.
- Administer the lowest effective dose for maintenance.
Adolescents
- It should not exceed 100 mg per day.
Older Adults
- Avoid use in older adults due to strong anticholinergic and sedative effects it may cause orthostatic hypotension.
- Use alternatives drugs. If must use, initiate with a lower initial dose.
- Initially, 50 mg per day orally is given. It may increase up to 100 mg per day.
Adverse effects
There are the following side effects of trimipramine:
- Fatigue
- Weakness
- Constipation
- Sedation
- Blurred vision
- Lethargy
- Insomnia
- Anxiety
- Dry mouth
- Vomiting
- Agitation
- Headache
- Nausea
- Sweating
- Rash
- ECG changes,
- Orthostatic hypotension
- Tachycardia
- Increased LFTs
- Sexual dysfunction
- Eosinophilia
- Seizures
- Thrombocytopenia
- Confusion,
- Extrapyramidal symptoms (EPS)
- Dizziness
- Paresthesia
- Tinnitus
- Agranulocytosis
- SIADH
- Leukopenia
Warnings
Following are the warnings that must know while using Imipramine
- In short-term studies, antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults (<24 yr of age) taking antidepressants for major depressive disorders and other psychiatric illnesses.
- This increase was not seen in patients aged >24 years. A slight decrease in suicidal thinking was seen in adults >65 years.
- In children and young adults, risks must be weighed against the benefits of taking antidepressants.
- Patients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies. This should be done during the initial 1-2 months of therapy and dosage adjustments.
- The patient’s family should communicate any abrupt changes in behavior to the healthcare provider.
- Worsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapy.
- This drug is not approved for use in pediatric patients.
Contraindications
There are the following contraindications of Clomipramine
- Acute recovery post-MI
- Narrow-angle glaucoma
- Severe cardiovascular disorder
- Any drugs or conditions that prolong QT interval.
Cautions
- BPH, urinary/GI retention, increases IOP, hyperthyroidism, open-angle glaucoma, seizure disorder, brain tumor, respiratory impairment
- Clinical worsening and suicide ideation may occur despite medication.
- Risk of anticholinergic side-effects
- Risk of mydriasis; may trigger angle closure attack in patients with angle-closure glaucoma with anatomically narrow angles without a patent iridectomy
Pregnancy
Lactation
Avoid its use during lactation. It is distributed in breast milk.
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