Desipramine – Usages, Side effects, Risk factors, Precautions

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Desipramine – Usages, Side effects, Risk factors, Precautions

Here in this post, we are discussing the “Desipramine”. You can read usages, side effects, Risk factors, and warning information.  Keep visiting Psychology Roots.

About Desipramine

Desipramine is an antidepressant TCAs.

Brand name

Desipramine is available with the following brand name.

  • Norpramin

Forms of Desipramine

Desipramine is available in the following form

  • Tablets

Tablets

Desipramine tablets are available in the following doses

  • 10mg
  • 25mg
  • 50mg
  • 75mg
  • 100mg
  • 150mg
Desipramine - Usages, Side effects, Risk factors, Precautions

Desipramine – Usages, Side effects, Risk factors, Precautions

Disorder to treat 

It is used for the treatment of the following disorder

Depression 

Adults 

  • Orally 100-200 mg every night at bedtime or divided into every 12 hr.
  • Up to 300 mg per day in severe cases.

Adolescents

  • <12 years: Safety and efficacy not established.
  • Initially, 25-50 mg orally is given every day. It may gradually increase if needed to 100 mg per day orally every day or divided into every 8-12hr. But it may not exceed 150 mg per day.

Older Adults 

  • Orally 25-100 mg every night at bedtime or divided into every 12hr.

Adverse effects

There are the following side effects of desipramine:

  • Fatigue
  • Weakness
  • Lethargy
  • Constipation
  • Dry mouth
  • Agitation
  • Blurred vision
  • Anxiety
  • Sedation
  • Headache
  • Nausea
  • Vomiting
  • Insomnia
  • Sweating

Infrequent

  • Confusion, dizziness, paresthesia
  • Elevated LFTs
  • ECG changes, orthostatic hypotension, tachycardia
  • Rash
  • Tinnitus
  • Extrapyramidal symptoms
  • Sexual dysfunction

Rare

  • Seizure
  • Leukopenia
  • SIADH
  • Agranulocytosis
  • Thrombocytopenia
  • Eosinophilia

Warnings

  • In short-term studies, antidepressants increased the risk of suicidal thinking and behaviour in children, adolescents, and young adults (<24 years) taking antidepressants for major depressive disorders and other psychiatric illnesses. This increase was not seen in patients aged >24 years.
  • A slight decrease in suicidal thinking was seen in adults >65 years. In children and young adults, risks must be weighed against the benefits of taking antidepressants. Patients should be monitored closely for changes in behaviour, clinical worsening, and suicidal tendencies. This should be done during the initial 1-2 months of therapy and dosage adjustments. The patient’s family should communicate any abrupt changes in behaviour to the healthcare provider
  • Worsening behaviour and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapy.
  • This drug is not approved for use in pediatric patients.

Contraindications

There are the following contraindications of desipramine

  • Hypersensitivity.
  • Severe cardiovascular disorder
  • Narrow-angle glaucoma.
  • Any drugs or conditions that prolong QT interval.
  • Acute recovery post-MI

Cautions

  • Caution with a family history of
    • Sudden death
    • Cardiac dysrhythmias
    • Cardiac conduction disturbances
    • Reports of cardiac dysrhythmias and death preceded by seizures
  • BPH, urinary/GI retention, hyperthyroidism, seizure disorder, brain tumour, respiratory impairment.
  • Risk of anticholinergic side effects
  • Risk of mydriasis; may trigger angle closure attack in patients with angle-closure glaucoma with anatomically narrow angles without a patent iridectomy
  • Potentially life-threatening serotonin syndrome reported when coadministered with drugs that impair serotonin metabolism (in particular, MAOIs, including non-psychiatric MAOIs, such as linezolid and IV methylene blue)

Pregnancy

Lactation

  • It is distributed in breast milk.

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